If your Skype tends to quit unexpectedly or get errors, it is a good to perform a clean uninstallation to give the app a fresh start. We try our best to keep things fair and balanced, in order to help you make the best choice for you. Tip: The easier and quickest way to uninstall either Skype or Skype for Business is to use the dedicated and best uninstaller for Mac, i.e., CleanMyMac X. This document provides you the steps to uninstall Microsoft Skype using Desktop Central. If you want to free up more storage on Mac, you can also use MacMaster to clean duplicate files, system trashes, large and old files. Uninstall Skype on Mac entirely Choose “Go to Folder…” from the Finder “Go” drop-down list. If any of its processes are running, you will not be able to uninstall it completely. Delete Skype for Business login from here. After scanning, all the downloaded applications will be displayed. Exit Skype For Business on Mac if it's running. Head to Applications > Utilities > Terminal.